Current Issue : January - March Volume : 2015 Issue Number : 1 Articles : 5 Articles
Mimusops elengi bark possesses cardiotonic activity as per Ayurvedic books and literature. Present study was carried out to find better and safer herbal cardiotonic alternate of digoxin by evaluating cardiotonic activity of ethanolic extract of bark of Mimusops elengi. The present study was carried out to evaluate positive inotropic effects of extract of bark of Mimusops elengi. Cardiotonic activity of ethanolic extract of the bark of Mimusops elengi Linn was studied against 1/4th calcium chloride induced congestive heart failure in isolated perfused rat heart method. Biochemical study of 15 days for evaluation of cardiac activity of ethanolic extract of Mimusops elengi bark on cardiac enzymes and cytosolic Ca2+ level was also performed. Ethanolic extract of Mimusops elengi showed significant (p<0.001) increased in force of contraction and cardiac output in hypodynamic heart preparations. It significantly increased cytoplasmic Ca2+ level after 15 day treatment but didn’t alter cardiac enzymes level i.e. didn’t alter normal physiology of heart. Present research work emphasizes cardiotonic potential and therapeutic usefulness of bark of Mimusops elengi as better alternate of digoxin in management of congestive heart failure....
In current stressful routine life style, depression has become the second most common chronic condition in clinical psychiatric practice. Echinops echinatus Roxb, (Compositae), commonly known as ‘Brahmadandi’, possesses several medicinal properties; but, little is known about its traditional use as nerve tonic. The objective of the present study was to evaluate the antidepressant activity of methanol extract of roots bark of Echinops echinatus using forced swim behavior despair models. E. echinatus roots were dried and extracted with methanol in soxhlet apparatus for 5-6 hr. Adult Wistar Albino rats were subjected to behavior despair test using Imipramine as reference standard. The alcohol extract of root bark of E. echinatus s (100, 200 and 400 mg/kg, p.o.) showed significant dose-dependent reduction in duration of immobility (P<0.01) in behavior despair test. The phytochemical screening revealed the presence of carbohydrate, sterols, terpenoid, flavonoid, glycoside, phenol and tannins in the roots bark of E. echinatus. The results showed that the plant possesses dose dependent antidepressant activity, confirming the traditional claims. Future research should focus on the isolation and identification of the phytoconstituents responsible for the antidepressant activity of E. echinatus roots....
In present study formulation and evaluation of polyherbal wound healing gel by using selected plant extracts reported to possess antibacterial and antinflammatory activities like Curcuma longa, Plumbago zeylenica and Aloe barbadensis with sodium CMC as a gel forming polymer. The individual herbs were evaluated for their standard specification according to the WHO guideline and Ayurvedic Pharmacopeia of India. Extract were obtained by established procedures. Standardization of the extracts was done. Phytochemical test and TLC fingerprinting of the extracts was carried out for identification and confirmation of some known active constituent present in the herbs. The gel was prepared by using accurately weighed amount of extracts along with additives. All the prepared gel formulations were subjected for preliminary evaluation such as appearance, pH, viscosity and spreadability. All the selected plant material was found to be within the pharmacopoeial limits. Preliminary phytochemical analysis and TLC fingerprinting studies confirmed the presence of reported bioactive constituent, all the extracts were found to contain fairly good content of phenolics and extract proved to possess wound healing activity. From the formulation studies it was clearly evident that both gel formulations showed good gelling property and homogeneity. The pH of all formulation was in the range of 6-7.5 which lies in the normal pH range of skin. The obtained results of wound healing activity of formulation were encouraging, formulation A produced better wound healing activity than formulation B.100% wound closure was observed by the 14th post wound day in both gel formulations, formulation A of the extract and the standard. The developed formulation A proved to be beneficial in the treatment of wound healing....
Metabolic disorders that involve elevations of lipoproteins species are termed as hyperlipidemias. The preliminary phytochemical analysis of ethanolic extract of Thespesia populnea was carried out for presence of alkaloids, saponins, tannins, glycosides, steroids, carbohydrates, flavonoids, terpenoids and proteins in EETP. DPPH radical scavenging activity of EETP at various concentrations was done. High fat diet developed hyperlipidemia in rats but in the presence of fifteen days treatment of EETP and atorvastatin (10 mg/kg) significantly (P<0.0001) reduced elevated cholesterol and triglycerides level in comparison with HFD group. EETP 400 mg/kg found to be more antihypercholesteromic. EETP 200 mg/kg and EETP 400 mg/kg caused 36% and 44% reduction in TC level respectively in dose dependant manner. EETP treatment caused significant (P<0.0001) decrease liver cholesterol and increase in fecal cholesterol content. It reveals that EETP possess significant HMG CoA reductase inhibitory activity. Thus, it was presumed that the mode of action of EETP may similar to that of atrovastatin. Oral administration of EETP and atorvastatin prevented the high fat diet induced elevation of MDA in the liver homogenates. In our study, a rise in liver GSH level was observed in EETP as well as atorvastatin treated rats. It may be due to an increased biosynthesis of GSH or improved glutathione reductase activity in the presence of EETP. Oral feeding of EETP and atorvastatin resulted in reversal of decline of SOD and CAT levels in rats treated with high fat diet. We hypothesize that EETP exerted a beneficial effect by controlling ROS formation....
Studying medicinal plants to determine their potential as sources of new drugs is more important in recent times. The present study was carried out to investigate fibrinolytic and antioxidant activity of methanol extract of Commiphora caudata bark. In-vitro clot lysis was done by using urokinase as standard and the total antioxidant activity of extract was evaluated by the phosphomolybdenum assay method. The methanol extract of Commiphora caudata bark based on the percentage of clot lysis showed highest fibrinolytic and antioxidant activity equivalent to ascorbic acid. The present study revealed the fibrinolytic and antioxidant activity potential of methanol extract of Commiphora caudata bark....
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